A sign calling attention to drug overdoses is posted to the door of a gas station on the White Earth Reservation in Ogema, Minn. Credit: David Goldman/AP

More Americans died of drug overdoses in 2021 than any previous year, a grim milestone in an epidemic that has now claimed 1 million lives in the 21st century, according to federal data released Wednesday.

More than 100,000 Americans died of drug overdoses in 2021, up 15 percent from the previous year, according to an estimate released by the National Center for Health Statistics. The tally of 107,622 reflects challenges exacerbated by the coronavirus pandemic: lost access to treatment, social isolation and a more potent drug supply.

More than 80,000 people died using opioids, including prescription pain pills and fentanyl, a deadly drug 100 times as powerful as morphine and increasingly present in other drugs. Deaths from methamphetamine and cocaine also rose.

Since the start of the 21st century, an overdose epidemic led by prescription pain pills and followed by waves of heroin, fentanyl and meth has killed […]

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