Women actively infected with genital herpes during early pregnancy had twice the odds of giving birth to a child later diagnosed with autism spectrum disorder (ASD), according to a study by scientists at the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health and the Norwegian Institute of Public Health.

The study is the first to provide immunological evidence on the role of gestational infection in autism, reporting an association between maternal anti-herpes simplex virus-2 (HSV-2) antibodies and risk for ASD in offspring. Results appear in mSphere, a journal of the American Society for Microbiology.

“We believe the mother’s immune response to HSV-2 could be disrupting fetal central nervous system development, raising risk for autism,” says lead author Milada Mahic, a post-doctoral research scientist with the Center for Infection and Immunity and the Norwegian Institute of Public Health.

The authors do not believe that the risk is due to direct infection of the fetus because such infections are typically fatal. Instead, they suggest that neurodevelopmental outcomes are due to primary or reactivation of infection […]

Read the Full Article